Article
Antigen-specific apheresis of pathogenic autoantibodies from myasthenia gravis sera.
Annals of the New York Academy of Sciences - 1 Jan 2008
Tzartos Socrates J, Bitzopoulou Kalliopi, Gavra Ira, Kordas Grigoris, Jacobson Leslie, Kostelidou Kalliopi, Lagoumintzis George, Lazos Orestis, Poulas Kostantinos, Sideris Sotiris, Sotiriadis Alexandros, Trakas Nikos, Zisimopoulou Paraskevi
Abstract excerpt
Myasthenia gravis (MG) is usually caused by autoantibodies against muscle nicotinic acetylcholine receptor (AChR), which is composed of five subunits (alpha(2)betagammadelta or alpha(2)betaepsilondelta). Current treatments, including plasmapheresis, are nonspecific, causing several side effects. We aim to develop an antigen-specific alternative to plasmapheresis, since the latter removes indispensable plasma...
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