Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Prefrontal executive function and D1, D3, 5-HT2A and 5-HT6 receptor gene variations in healthy adults.

Journal of psychiatry & neuroscience : JPN - 1 Jan 2008

Lane Hsien-Yuan, Liu Yi-Ching, Huang Chieh-Liang, Hsieh Ching-Liang, Chang Yi-Lin, Chang Lauren, Chang Yue-Cune, Chang Wen-Ho

Abstract excerpt

OBJECTIVE: The Val158Met polymorphism of the catechol-O-methyltransferase gene has been demonstrated to be associated with prefrontal executive function explaining 4% of variance in perseverative errors on the Wisconsin Card Sorting Test (WCST). Studies suggest that dopamine D(1) and D(3) and serotonin 5-HT(2A) and 5-HT(6) receptors may also be involved in prefrontal cognitive function and that genetic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cognition
Share to DNA Primers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Health Status

Share to Prefrontal Cortex

Share to Receptor, Serotonin, 5-HT2A

Share to Receptors, Dopamine D1

Share to Receptors, Dopamine D3

Share to Receptors, Serotonin

Source

Open in PubMed Open full text

Identifiers

PMID: 18197272
PMCID: PMC2186374

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prefrontal executive function and D1, D3, 5-HT2A and 5-HT6 receptor gene variations in healthy adults.PMID 18197272Read ↗

Effects of the catechol-O-methyltransferase Val158Met polymorphism on executive function: a meta-analysis of the Wisconsin Card Sort Test in schizophrenia and healthy controls.Semantic proximity Read ↗

A functional polymorphism in the COMT gene and performance on a test of prefrontal cognition.Semantic proximity Read ↗

COMT Val158Met Genotype and Individual Differences in Executive Function in Healthy Adults.Semantic proximity Read ↗

Performance in the Wisconsin Card Sorting Test and the C957T polymorphism of the DRD2 gene in healthy volunteers.Semantic proximity Read ↗

Impact of five SNPs in dopamine-related genes on executive function.Semantic proximity Read ↗

Meta-analysis of the cognitive effects of the catechol-O-methyltransferase gene Val158/108Met polymorphism.Semantic proximity Read ↗

Catechol-o-methyltransferase gene and executive function in children with ADHD.Semantic proximity Read ↗

Impact of the COMT Val108/158 Met and DAT genotypes on prefrontal function in healthy subjects.Semantic proximity Read ↗

A Potential Role of the 5-HTTLPR Polymorphism in Self-Reported Executive Functioning.Semantic proximity Read ↗

Effects of two dopamine-modulating genes (DAT1 9/10 and COMT Val/Met) on n-back working memory performance in healthy volunteers.Semantic proximity Read ↗

Association study of a functional catechol-O-methyltransferase polymorphism and executive function in elderly males without dementia.Semantic proximity Read ↗

Genes, cognition and brain through a COMT lens.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.