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Article

Regulation of EGFR and Notch signaling by distinct isoforms of D-cbl during Drosophila development.

Developmental biology - 1 Jun 2010

Wang Yuan, Chen Zhihong, Bergmann Andreas

Abstract excerpt

Cells receive and interpret extracellular signals to regulate cellular responses such as proliferation, cell survival and differentiation. However, proper inactivation of these signals is critical for appropriate homeostasis. Cbl proteins are E3-ubiquitin ligases that restrict receptor tyrosine kinase (RTK) signaling, most notably EGFR (Epidermal Growth Factor Receptor), via the endocytic pathway. Consistently,...

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Identifiers

PMID: 20302857
DOI: 10.1016/j.ydbio.2010.03.005
PMCID: PMC2866751

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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