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Article

Differential effects of Cbl isoforms on Egfr signaling in Drosophila.

Mechanisms of development - 1 Jun 2006

Pai Li-Mei, Wang Pei-Yu, Chen Shu-Ru, Barcelo Gail, Chang Wei-Ling, Nilson Laura, Schüpbach Trudi

Abstract excerpt

The Cbl family of proteins downregulate epidermal growth factor receptor (Egfr) signaling via receptor internalization and destruction. These proteins contain two functional domains, a RING finger domain with E3 ligase activity, and a proline rich domain mediating the formation of protein complexes. The Drosophila cbl gene encodes two isoforms, D-CblS and D-CblL. While both contain a RING finger domain, the...

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Identifiers

PMID: 16844358
DOI: 10.1016/j.mod.2006.04.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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