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Article

Innocuous IFNgamma induced by adjuvant-free antigen restores normoglycemia in NOD mice through inhibition of IL-17 production.

The Journal of experimental medicine - 21 Jan 2008

Jain Renu, Tartar Danielle M, Gregg Randal K, Divekar Rohit D, Bell J Jeremiah, Lee Hyun-Hee, Yu Ping, Ellis Jason S, Hoeman Christine M, Franklin Craig L, Zaghouani Habib

Abstract excerpt

The role of Th17 cells in type I diabetes (TID) remains largely unknown. Glutamic acid decarboxylase (GAD) sequence 206-220 (designated GAD2) represents a late-stage epitope, but GAD2-specific T cell receptor transgenic T cells producing interferon gamma (IFNgamma) protect against passive TID. Because IFNgamma is known to inhibit Th17 cells, effective presentation of GAD2 peptide under noninflammatory conditions...

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Source

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Identifiers

PMID: 18195074
DOI: 10.1084/jem.20071878
PMCID: PMC2234380

Genes

GAD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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