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Article

Identification of immunogenic epitopes of GAD 65 presented by Ag7 in non-obese diabetic mice.

Immunogenetics - 1 Jan 1997

Chao C C, McDevitt H O

Abstract excerpt

The autoantigen glutamic acid decarboxylase 65 (GAD 65) is believed to be an important target antigen in insulin-dependent diabetes mellitus (IDDM), since an age-related spontaneous breakdown in tolerance is observed, and cell-mediated and autoantibody immune responses have been reported in humans and NOD mice. We sought to identify immunogenic epitopes of GAD 65 which are presented to T cells by the type I...

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Identifiers

PMID: 9148785
DOI: 10.1007/s002510050238

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