Article
Identification of immunogenic epitopes of GAD 65 presented by Ag7 in non-obese diabetic mice.
Immunogenetics - 1 Jan 1997
Chao C C, McDevitt H O
Abstract excerpt
The autoantigen glutamic acid decarboxylase 65 (GAD 65) is believed to be an important target antigen in insulin-dependent diabetes mellitus (IDDM), since an age-related spontaneous breakdown in tolerance is observed, and cell-mediated and autoantibody immune responses have been reported in human...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Antigen Presentation
- Autoantigens
- Epitope Mapping
- Female
- Glutamate Decarboxylase
- Histocompatibility Antigens Class II
- Hybridomas
- Immunodominant Epitopes
- Mice
