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Article

Eosinophil-derived neurotoxin acts as an alarmin to activate the TLR2-MyD88 signal pathway in dendritic cells and enhances Th2 immune responses.

The Journal of experimental medicine - 21 Jan 2008

Yang De, Chen Qian, Su Shao Bo, Zhang Ping, Kurosaka Kahori, Caspi Rachel R, Michalek Suzanne M, Rosenberg Helene F, Zhang Ning, Oppenheim Joost J

Abstract excerpt

Eosinophil-derived neurotoxin (EDN) is an eosinophil granule-derived secretory protein with ribonuclease and antiviral activity. We have previously shown that EDN can induce the migration and maturation of dendritic cells (DCs). Here, we report that EDN can activate myeloid DCs by triggering the Toll-like receptor (TLR)2-myeloid differentiation factor 88 signaling pathway, thus establishing EDN as an endogenous...

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Share to Dendritic Cells
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Myeloid Differentiation Factor 88

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Source

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Identifiers

PMID: 18195069
DOI: 10.1084/jem.20062027
PMCID: PMC2234357

Genes

TLR2
TLR1
TLR6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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