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Article

High-mobility group nucleosome-binding protein 1 acts as an alarmin and is critical for lipopolysaccharide-induced immune responses.

The Journal of experimental medicine - 16 Jan 2012

Yang De, Postnikov Yuri V, Li Yana, Tewary Poonam, de la Rosa Gonzalo, Wei Feng, Klinman Dennis, Gioannini Theresa, Weiss Jerrold P, Furusawa Takashi, Bustin Michael, Oppenheim Joost J

Abstract excerpt

Alarmins are endogenous mediators capable of promoting the recruitment and activation of antigen-presenting cells (APCs), including dendritic cells (DCs), that can potentially alert host defense against danger signals. However, the relevance of alarmins to the induction of adaptive immune responses remains to be demonstrated. In this study, we report the identification of HMGN1 (high-mobility group...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22184635
DOI: 10.1084/jem.20101354
PMCID: PMC3260868

Genes

HMGN1
TLR4

Provenance

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