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Article

Macroautophagy is required for multicellular development of the social amoeba Dictyostelium discoideum.

The Journal of biological chemistry - 16 May 2003

Otto Grant P, Wu Mary Y, Kazgan Nevzat, Anderson O Roger, Kessin Richard H

Abstract excerpt

Macroautophagy is a mechanism employed by eukaryotic cells to recycle non-essential cellular components during starvation, differentiation, and development. Two conjugation reactions related to ubiquitination are essential for autophagy: Apg12p conjugation to Apg5p, and Apg8p conjugation to the lipid phosphatidylethanolamine. These reactions require the action of the E1-like enzyme, Apg7p, and the E2-like...

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Identifiers

PMID: 12626495
DOI: 10.1074/jbc.M212467200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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