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Transcript levels of DNA methyltransferases DNMT1, DNMT3A and DNMT3B in CD4<sup>+</sup>T cells from patients with systemic lupus erythematosus

24 Jan 2008

Abstract excerpt

Global DNA hypomethylation in CD4(+) T cells has been detected in systemic lupus erythematosus (SLE) and it seems to be linked to its pathogenesis. We investigated the relationship between overall DNA methylation and the expression of three DNA (cytosine-5) methyltransferases involved in the DNA methylation process. The DNA deoxymethylcytosine (dmC) content of purified CD4(+) T cells from 29 SLE patients and 30...

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PMID: 18194272
DOI: 10.1111/j.1365-2567.2007.02771.x

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