Article
Genetic variants of DNMT3A and systemic lupus erythematosus susceptibility.
Modern rheumatology - 1 Jan 2015
Piotrowski Piotr, Grobelna Malwina K, Wudarski Mariusz, Olesińska Marzena, Jagodziński Paweł P
Abstract excerpt
OBJECTIVES: A significant increase in DNA methyltransferase 3A (DNMT3A) transcript levels has recently been demonstrated in peripheral blood mononuclear cells from systemic lupus erythematosus (SLE) patients as compared to healthy individuals. METHODS: Employing high resolution melting curve analysis (HRM) and PCR-restriction fragment length polymorphism analysis, we assessed the frequency of five single...
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