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Abnormal DNA methylation in T cells from patients with subacute cutaneous lupus erythematosus

17 Jul 2008

Abstract excerpt

BACKGROUND: Impaired methylation of T-cell DNA is thought to contribute to the development of systemic lupus erythematosus. However, it is unknown whether T-cell hypomethylation is a factor in other, less severe, forms of lupus erythematosus such as subacute cutaneous lupus erythematosus (SCLE). OBJECTIVES: To investigate global DNA methylation and the expression of genes that regulate methylation in T cells of...

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PMID: 18644019
DOI: 10.1111/j.1365-2133.2008.08758.x

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