Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pharmacogenetics of cyclosporine in children suggests an age-dependent influence of ABCB1 polymorphisms.

Pharmacogenetics and genomics - 1 Feb 2008

Fanta Samuel, Niemi Mikko, Jönsson Siv, Karlsson Mats O, Holmberg Christer, Neuvonen Pertti J, Hoppu Kalle, Backman Janne T

Abstract excerpt

OBJECTIVE: To evaluate whether variations in the ABCB1, ABCC2, SLCO1B1, CYP3A4, CYP3A5, or NR1I2 genes are associated with the pharmacokinetics of cyclosporine in pediatric renal transplant candidates, and whether the effects of these variants are related to age. METHODS: A total of 104 pediatric patients (aged 0.36-16.3 years) were genotyped for 17 putatively functionally significant sequence variations in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age Factors
Share to ATP Binding Cassette Transporter, Subfamily B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ATP Binding Cassette Transporter, Subfamily B, Member 1

Share to Cyclosporine

Share to DNA Primers

Share to Infant

Share to Multidrug Resistance-Associated Protein 2

Share to Pharmacogenetics

Source

Identifiers

PMID: 18192894
DOI: 10.1097/FPC.0b013e3282f3ef72

Genes

ABCB1
ABCC2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pharmacogenetics of cyclosporine in children suggests an age-dependent influence of ABCB1 polymorphisms.PMID 18192894Read ↗

A drug transporter for all ages? ABCB1 and the developmental pharmacogenetics of cyclosporine.Semantic proximity Read ↗

Effect of Age and Allele Variants of CYP3A5, CYP3A4, and POR Genes on the Pharmacokinetics of Cyclosporin A in Pediatric Renal Transplant Recipients From Serbia.Semantic proximity Read ↗

Long-term changes in cyclosporine pharmacokinetics after renal transplantation in children: evidence for saturable presystemic metabolism and effect of NR1I2 polymorphism.Semantic proximity Read ↗

Population pharmacokinetics of cyclosporine in kidney and heart transplant recipients and the influence of ethnicity and genetic polymorphisms in the MDR-1, CYP3A4, and CYP3A5 genes.Semantic proximity Read ↗

CYP3A5 and MDR1 genetic polymorphisms and cyclosporine pharmacokinetics after renal transplantationSemantic proximity Read ↗

Effect of CYP3A and ABCB1 single nucleotide polymorphisms on the pharmacokinetics and pharmacodynamics of calcineurin inhibitors: Part I.Semantic proximity Read ↗

Long-term effects of ABCB1 and SXR SNPs on the systemic exposure to cyclosporine in pediatric kidney transplant patients.Semantic proximity Read ↗

Pharmacogenetics in immunosuppressants: impact on dose requirement of calcineurin inhibitors in renal and liver pediatric transplant recipients.Semantic proximity Read ↗

Frequencies and roles of CYP3A5, CYP3A4 and ABCB1 single nucleotide polymorphisms in Italian teenagers after kidney transplantation.Semantic proximity Read ↗

Optimizing immunosuppressive drug dosing in pediatric renal transplantation. Part of a special series on Paediatric Pharmacology, guest edited by Gianvincenzo Zuccotti, Emilio Clementi, and Massimo Molteni.Semantic proximity Read ↗

Effect of CYP3A and ABCB1 single nucleotide polymorphisms on the pharmacokinetics and pharmacodynamics of calcineurin inhibitors: Part II.Semantic proximity Read ↗

Explaining variability in ciclosporin exposure in adult kidney transplant recipients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.