Long-term effects of ABCB1 and SXR SNPs on the systemic exposure to cyclosporine in pediatric kidney transplant patients.

doi:10.2217/pgs.13.148

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Article

Long-term effects of ABCB1 and SXR SNPs on the systemic exposure to cyclosporine in pediatric kidney transplant patients.

Pharmacogenomics - 1 Oct 2013

Ferraresso Mariano, Belingheri Mirco, Turolo Stefano, Ghio Luciana, Tirelli Amedea Silvia, Grillo Paolo, Lepore Marta, Edefonti Alberto

Abstract excerpt

AIM: Cyclosporine is characterized by a wide interindividual variability in its pharmacokinetics. The objective of this study was to evaluate the effects of ABCB1 and SXR SNPs on cyclosporine exposure in a group of kidney transplant patients followed up from childhood to adulthood. PATIENTS & METHODS: Recipients were genotyped for ABCB1 C1236T, G2677T/A and C3435T, and for SXR RS3842689 and A7635G. Dose-adjusted...

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Share to ATP Binding Cassette Transporter, Subfamily B

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Identifiers

PMID: 24088131
DOI: 10.2217/pgs.13.148

Genes

ABCB1

Variants

RS3842689
RS3842689
RS3842689
RS3842689

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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