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Article

Functional analysis and molecular dynamics simulation of LOX-1 K167N polymorphism reveal alteration of receptor activity.

PloS one - 1 Jan 2009

Biocca Silvia, Falconi Mattia, Filesi Ilaria, Baldini Francesco, Vecchione Lucia, Mango Ruggiero, Romeo Francesco, Federici Giorgio, Desideri Alessandro, Novelli Giuseppe

Abstract excerpt

The human lectin-like oxidized low density lipoprotein receptor 1 LOX-1, encoded by the ORL1 gene, is the major scavenger receptor for oxidized low density lipoprotein in endothelial cells. Here we report on the functional effects of a coding SNP, c.501G>C, which produces a single amino acid chan...

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Identifiers

PMID: 19247493
DOI: 10.1371/journal.pone.0004648
PMCID: PMC2645694

Genes

LOX

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19247493-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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