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Article

Differential interleukin-10 production stratified by -571 promoter polymorphism in purified human immune cells.

Cellular immunology - 1 Oct 2007

Steinke John W, Barekzi Elizabeth, Huyett Phillip, Borish Larry

Abstract excerpt

A C-to-A base substitution has been identified at bp -571 in the IL-10 promoter and has been linked to numerous diseases. To investigate the role of this polymorphism on IL-10 production, T cells, B cells and monocytes were enriched from peripheral blood from subjects either homozygous for the C or A allele. Treatment of monocytes and B cells with lipopolysaccharide from individuals homozygous for the C allele...

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Identifiers

PMID: 18191118
DOI: 10.1016/j.cellimm.2007.12.001
PMCID: PMC2274832

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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