Article
Mosaics of gene variations in the Interleukin-10 gene promoter affect interleukin-10 production depending on the stimulation used.
Genes and immunity - 1 Jun 2004
Mörmann M, Rieth H, Hua T D, Assohou C, Roupelieva M, Hu S L, Kremsner P G, Luty A J F, Kube D
Abstract excerpt
Interleukin-10 (IL-10), a cytokine involved in many aspects of the immune response shows interindividual variations in their expression. However, genetic variations of the 5'-flanking region of the IL-10 gene (PIL-10) are poorly characterised with respect to different stimuli. New extended haplo- and genotypes are identified present at differing frequencies in three geographically separated populations. Their...
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