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Article

Interleukin 10 secretion in relation to human IL-10 locus haplotypes.

Proceedings of the National Academy of Sciences of the United States of America - 4 Aug 1998

Eskdale J, Gallagher G, Verweij C L, Keijsers V, Westendorp R G, Huizinga T W

Abstract excerpt

Stimulation of human blood cultures with bacterial lipopolysaccharide (LPS) shows large inter-individual variation in interleukin 10 (IL-10) secretion, which has been shown to have a genetic component of over 70%. Alleles at two microsatellite loci in the 4 kb immediately upstream of the human IL-10 transcription initiation site in 132 individuals from 56 Dutch families were defined and assigned as haplotypes....

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Identifiers

PMID: 9689103
DOI: 10.1073/pnas.95.16.9465
PMCID: PMC21361

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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