Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polymorphisms in the catechol-O-methyltransferase (COMT) gene influence plasma total homocysteine levels.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Sept 2008

Tunbridge Elizabeth M, Harrison Paul J, Warden Donald R, Johnston Carole, Refsum Helga, Smith A David

Abstract excerpt

Elevated plasma total homocysteine (tHcy) is a risk factor for various disorders. We investigated whether functional polymorphisms in catechol-O-methyltransferase (COMT) influence tHcy, since COMT activity produces S-adenosylhomocysteine (SAH), a homocysteine precursor. We hypothesized that high activity COMT variants would be associated with high tHcy, since they presumably result in increased formation of SAH....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Catechol O-Methyltransferase

Share to Epistasis, Genetic

Share to Homocysteine

Share to Linkage Disequilibrium

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Models, Biological

Source

Identifiers

PMID: 18189241
DOI: 10.1002/ajmg.b.30700

Genes

COMT
MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polymorphisms in the catechol-O-methyltransferase (COMT) gene influence plasma total homocysteine levels.PMID 18189241Read ↗

The catechol-O-methyltransferase gene: its regulation and polymorphisms.Semantic proximity Read ↗

The enzymatic activities of brain catechol-O-methyltransferase (COMT) and methionine sulphoxide reductase are correlated in a COMT Val/Met allele-dependent fashion.Semantic proximity Read ↗

Catechol-O-methyltransferase genotype is associated with plasma total homocysteine levels and may increase venous thrombosis risk.Semantic proximity Read ↗

Functional COMT Val158Met polymorphism, risk of acute coronary events and serum homocysteine: the Kuopio ischaemic heart disease risk factor study.Semantic proximity Read ↗

Polymorphisms in catechol-O-methyltransferase and methylenetetrahydrofolate reductase in relation to the risk of schizophrenia.Semantic proximity Read ↗

Prevalence of COMT Val158Met polymorphism in Eastern UP population.Semantic proximity Read ↗

Catechol-O-methyltransferase polymorphisms and some implications for cognitive therapeutics.Semantic proximity Read ↗

Comprehensive interrogation of CpG island methylation in the gene encoding COMT, a key estrogen and catecholamine regulatorSemantic proximity Read ↗

Distribution of the Val108/158Met polymorphism of the COMT gene in healthy Mexican population.Semantic proximity Read ↗

Association of Catechol-O-methyltransferase (COMT Val158Met) with future risk of cardiovascular disease in depressed individuals - a Swedish population-based cohort study.Semantic proximity Read ↗

In Silico Prediction of the Effects of Nonsynonymous Single Nucleotide Polymorphisms in the Human Catechol-O-Methyltransferase (COMT) Gene.Semantic proximity Read ↗

The Role of a Catechol-O-Methyltransferase (COMT) Val158Met Genetic Polymorphism in Schizophrenia: A Systematic Review and Updated Meta-analysis on 32,816 Subjects.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.