Article
Catechol-O-methyltransferase genotype is associated with plasma total homocysteine levels and may increase venous thrombosis risk.
Thrombosis and haemostasis - 1 Dec 2007
Gellekink Henkjan, Muntjewerff Jan-Willem, Vermeulen Sita H H M, Hermus Ad R M M, Blom Henk J, den Heijer Martin
Abstract excerpt
A disturbed methylation has been proposed as a mechanism via which homocysteine is associated with diseases like vascular disease, neural tube defects and mental disorders. Catechol-O-methyltransferase (COMT) is involved in the S-adenosylmethionine-dependent methylation of catecholamines and catecholestrogens and in this way contributes to homocysteine synthesis. COMT dysfunction has been related to schizophrenia...
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