Article
NOD2 modulates immune tolerance via the GM-CSF-dependent generation of CD103+ dendritic cells.
Proceedings of the National Academy of Sciences of the United States of America - 19 May 2020
Prescott David, Maisonneuve Charles, Yadav Jitender, Rubino Stephen J, Girardin Stephen E, Philpott Dana J
Abstract excerpt
Four decades ago, it was identified that muramyl dipeptide (MDP), a peptidoglycan-derived bacterial cell wall component, could display immunosuppressive functions in animals through mechanisms that remain unexplored. We sought to revisit these pioneering observations because mutations in NOD2, the gene encoding the host sensor of MDP, are associated with increased risk of developing the inflammatory bowel disease...
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