Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reduced thermal hyperalgesia and enhanced peripheral nerve injury after hind paw inflammation in mice lacking the serotonin-transporter.

European journal of pain (London, England) - 1 Aug 2008

Palm Florian, Mössner Rainald, Chen Yong, He Lan, Gerlach Manfred, Bischofs Stefan, Riederer Peter, Lesch Klaus-Peter, Sommer Claudia

Abstract excerpt

Mice lacking the serotonin-transporter (5-HTT-/- mice) develop reduced thermal hyperalgesia after nerve injury, concomitant with reduced serotonin (5-HT) levels in nervous tissue. Here we investigated pain behaviour in 5-HTT-/- mice compared to their wild type littermates after hind paw inflammation induced by complete Freund's adjuvant (CFA). We used standard tests for pain behaviour, high performance liquid...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adjuvants, Immunologic
Share to Epidermis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ganglia, Spinal

Share to Hindlimb

Share to Hyperalgesia

Share to Neurons, Afferent

Share to Sciatic Nerve

Share to Serotonin

Source

Identifiers

PMID: 18187350
DOI: 10.1016/j.ejpain.2007.11.009

Genes

HTT
ATF3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reduced thermal hyperalgesia and enhanced peripheral nerve injury after hind paw inflammation in mice lacking the serotonin-transporter.PMID 18187350Read ↗

Activation of ERK/CREB pathway in noradrenergic neurons contributes to hypernociceptive phenotype in H4 receptor knockout mice after nerve injury.Semantic proximity Read ↗

Colon-to-hind paw cross-organ sensitization is partially mediated by TrkB.T1-facilitated spinal neuroinflammation to activate lumbar DRG neuronsSemantic proximity Read ↗

Behavioral phenotype, intestinal microbiome, and brain neuronal activity of male serotonin transporter knockout mice.Semantic proximity Read ↗

Serotonin-1A receptor polymorphism (rs6295) associated with thermal pain perception.Semantic proximity Read ↗

Sex-dependent effects of the targeted nerve growth factor mutation (R100E) on pain behavior, joint inflammation, and bone erosion in mice.Semantic proximity Read ↗

Behavioural phenotype of histamine H4 receptor knockout mice: Focus on central neuronal functions.Semantic proximity Read ↗

Behavioral Thermoceptive Responses and Morphologic Correlates in Mouse Models of CMT1A, HNPP and AgingSemantic proximity Read ↗

Genetic impairment of interleukin-1 signaling attenuates neuropathic pain, autotomy, and spontaneous ectopic neuronal activity, following nerve injury in mice.Semantic proximity Read ↗

Metalloproteinase MT5-MMP is an essential modulator of neuro-immune interactions in thermal pain stimulation.Semantic proximity Read ↗

At-level allodynia after mid-thoracic contusion in the ratSemantic proximity Read ↗

Nucleus raphe magnus serotonin neurons bidirectionally control spinal nociceptive transmission in miceSemantic proximity Read ↗

A pro-nociceptive phenotype unmasked in mice lacking fatty-acid amide hydrolase.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.