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Article

Detection of hMSH2 and hMLH1 mutations in Chinese hereditary non-polyposis colorectal cancer kindreds.

World journal of gastroenterology - 14 Jan 2008

Zhang Chang-Hua, He Yu-Long, Wang Fang-Jin, Song Wu, Yuan Xi-Yu, Yang Dong-Jie, Chen Chuang-Qi, Cai Shi-Rong, Zhan Wen-Hua

Abstract excerpt

AIM: To establish and validate the mutation testing for identification and characterization of hereditary non-polyposis colorectal cancer (HNPCC) in suspected Chinese patients. METHODS: Five independent Chinese kindreds with HNPCC fulfilling the classical Amsterdam criteria were collected. Genomic DNA was extracted after informed consent was obtained. The coding region of hMSH2 and hMLH1 genes was detected by...

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Identifiers

PMID: 18186571
DOI: 10.3748/wjg.14.298
PMCID: PMC2675130

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