Article
Novel DNA variants and mutation frequencies of hMLH1 and hMSH2 genes in colorectal cancer in the Northeast China population.
PloS one - 1 Jan 2013
Hu Fulan, Li Dandan, Wang Yibaina, Yao Xiaoping, Zhang Wencui, Liang Jing, Lin Chunqing, Ren Jiaojiao, Zhu Lin, Wu Zhiwei, Li Shuying, Li Ye, Zhao Xiaojuan, Cui Binbin, Dong Xinshu, Tian Suli, Zhao Yashuang
Abstract excerpt
Research on hMLH1 and hMSH2 mutations tend to focus on Lynch syndrome (LS) and LS-like colorectal cancer (CRC). No studies to date have assessed the role of hMLH1 and hMSH2 genes in mass sporadic CRC (without preselection by MSI or early age of onset). We aimed to identify novel hMLH1 and hMSH2 DNA variants, to determine the mutation frequencies and sites in both sporadic and LS CRC and their relationships with...
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