Article
Low mutation rate of hMSH2 and hMLH1 in Taiwanese hereditary non-polyposis colorectal cancer.
Clinical genetics - 1 Sept 2003
Wei S-C, Yu C-Y, Tsai-Wu J-J, Su Y-N, Sheu J-C, Wu C-H H, Wang C-Y, Wong J-M
Abstract excerpt
Hereditary non-polyposis colorectal cancer (HNPCC), the most common type of hereditary colorectal cancer, is thought to be a simple Mendelian disease involving DNA mismatch repair genes. The majority of mutations associated with HNPCC occur in the hMSH2 and hMLH1 genes. The reported incidence of...
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