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Article

Cis- and trans- loci influence expression of the schizophrenia susceptibility gene DTNBP1.

Human molecular genetics - 15 Apr 2008

Bray Nicholas J, Holmans Peter A, van den Bree Marianne B, Jones Lesley, Elliston Lyn A, Hughes Gareth, Richards Alexander L, Williams Nigel M, Craddock Nick, Owen Michael J, O'Donovan Michael C

Abstract excerpt

Susceptibility to complex disease appears to be partly mediated by heritable differences in gene expression. Where cis-acting effects on a gene's expression influence disease susceptibility, other genes containing polymorphism with a trans-acting effect on expression of that gene may also be expected to modulate risk. Use of the expression of an identified disease gene as an endophenotype for quantitative linkage...

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Source

Identifiers

PMID: 18182443
DOI: 10.1093/hmg/ddn006

Genes

DTNBP1
NRG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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