Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effects of cis-regulatory variation differ across regions of the adult human brain.

Human molecular genetics - 15 Nov 2010

Buonocore Federica, Hill Matthew J, Campbell Colin D, Oladimeji Paul B, Jeffries Aaron R, Troakes Claire, Hortobagyi Tibor, Williams Brenda P, Cooper Jonathan D, Bray Nicholas J

Abstract excerpt

Cis-regulatory variation is considered to be an important determinant of human phenotypic variability, including susceptibility to complex disease. Recent studies have shown that the effects of cis-regulatory polymorphism on gene expression can differ widely between tissues. In the present study, we tested whether the effects of cis-regulatory variation can also differ between regions of the adult human brain. We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Brain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to NOS1 gene

Share to RGS4 gene

Share to Phenotype

Share to Polymorphism, Genetic

Share to Regulatory Elements, Transcriptional

Source

Open in PubMed Open full text

Identifiers

PMID: 20829226
DOI: 10.1093/hmg/ddq380
PMCID: PMC3298852

Genes

AKT1
NOS1
RGS4
TCF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of cis-regulatory variation differ across regions of the adult human brain.PMID 20829226Read ↗

Cis-acting variation in the expression of a high proportion of genes in human brain.Semantic proximity Read ↗

Association between SNPs and gene expression in multiple regions of the human brain.Semantic proximity Read ↗

Genetic variability in the regulation of gene expression in ten regions of the human brain.Semantic proximity Read ↗

Modern human alleles differentially regulate gene expression across brain regions: implications for brain evolutionSemantic proximity Read ↗

Cis-acting regulatory variation in the human genome.Semantic proximity Read ↗

Illuminating links between cis-regulators and trans-acting variants in the human prefrontal cortexSemantic proximity Read ↗

Disruption of long-range gene regulation in human genetic disease: a kaleidoscope of general principles, diverse mechanisms and unique phenotypic consequences.Semantic proximity Read ↗

Mapping cis- and trans-regulatory effects across multiple tissues in twins.Semantic proximity Read ↗

Survey of the effect of genetic variations on gene expression in human prefrontal cortex and its application to genetics of psychiatric disorders.Semantic proximity Read ↗

Brain region-specific effects of nearly fixed sapiens-derived alleles.Semantic proximity Read ↗

Identification of Brain Expression Quantitative Trait Loci Associated with Schizophrenia and Affective Disorders in Normal Brain TissueSemantic proximity Read ↗

Impacts of variation in the human genome on gene regulation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.