Article
Genetic regulation of Nrxn1 [corrected] expression: an integrative cross-species analysis of schizophrenia candidate genes.
Translational psychiatry - 26 Jul 2011
Mozhui K, Wang X, Chen J, Mulligan M K, Li Z, Ingles J, Chen X, Lu L, Williams R W
Abstract excerpt
Neurexin 1 (NRXN1) is a large presynaptic transmembrane protein that has complex and variable patterns of expression in the brain. Sequence variants in NRXN1 are associated with differences in cognition, and with schizophrenia and autism. The murine Nrxn1 gene is also highly polymorphic and is associated with significant variation in expression that is under strong genetic control. Here, we use co-expression...
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