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Article

Identification of a novel and myeloid specific role of the leukemia‐associated fusion protein DEK‐NUP214 leading to increased protein synthesis

7 Jan 2008

Abstract excerpt

The t(6;9)(p22;q34) chromosomal translocation is found in a subset of patients with acute myeloid leukemia (AML). The translocation results in a fusion between the nuclear phosphoprotein DEK and the nucleoporin NUP214 (previously CAN). The mechanism by which the fusion protein DEK-NUP214 contributes to leukemia development has not been identified, and disruptions of normal cellular functions by DEK-NUP214 have...

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Identifiers

PMID: 18181180
DOI: 10.1002/gcc.20531

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