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XPO1-dependency of DEK::NUP214 leukemia

27 Mar 2025

Abstract excerpt

The nuclear export protein XPO1 interacts with nucleoporin 214 (NUP214) and has been implicated in the pathogenesis of SET::NUP214 acute myeloid leukemia (AML). We evaluated DEK::NUP214 (DN), characterizing a distinct AML entity, for its dependency on XPO1 in human AML models. Deletion of XPO1 in DN-positive FKH-1 cells revealed a strong dependency on XPO1. Pharmacologic inhibition of XPO1 by the...

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PMID: 40148556
DOI: 10.1038/s41375-025-02570-1

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