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Suppression of human tumor cell proliferation by Smurf2‐induced senescence

7 Jan 2008

Abstract excerpt

The limitation of proliferative potential in human somatic cells imposed by replicative senescence has been proposed as a mechanism of tumor suppression. The E3 ubiquitin ligase Smurf2 is up-regulated during replicative senescence in response to telomere shortening, and induces senescence when expressed adventitiously in early passage or telomerase-immortalized human fibroblasts. To investigate the generality of...

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PMID: 18181147
DOI: 10.1002/jcp.21337

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