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Article

Smurf2 Regulates the Senescence Response and Suppresses Tumorigenesis in Mice

3 May 2012

Abstract excerpt

The E3 ubiquitin ligase Smurf2 mediates ubiquitination and degradation of several protein targets involved in tumorigenesis and induces senescence in human cells. However, the functional role of Smurf2 in tumorigenesis has not been fully evaluated. In this study, we generated a mouse model of Smurf2 deficiency to characterize the function of this E3 ligase in tumorigenesis. Smurf2 deficiency attenuated p16...

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PMID: 22552287
DOI: 10.1158/0008-5472.can-11-3773

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