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Quantitative methylation-specific PCR for the detection of aberrant DNA methylation in liquid-based Pap tests

7 Jan 2008

Abstract excerpt

BACKGROUND: Aberrant promoter methylation of selective tumor suppressor genes has been detected in squamous intraepithelial lesions (SIL) and invasive cervical cancer. Identification of methylation profiles of genes that can distinguish high-grade SIL (HSIL) from low-grade SIL (LSIL), and cytologically negative for intraepithelial lesion or malignancy (NILM) residual liquid-based Papanicolaou (Pap) tests may be...

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PMID: 18181097
DOI: 10.1002/cncr.23258

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