Article
Family-based association of FKBP5 in bipolar disorder.
Molecular psychiatry - 1 Mar 2009
Willour V L, Chen H, Toolan J, Belmonte P, Cutler D J, Goes F S, Zandi P P, Lee R S, MacKinnon D F, Mondimore F M, Schweizer B, DePaulo J R, Gershon E S, McMahon F J, Potash J B
Abstract excerpt
The FKBP5 gene product forms part of a complex with the glucocorticoid receptor and can modulate cortisol-binding affinity. Variations in the gene have been associated with increased recurrence of depression and with rapid response to antidepressant treatment. We sought to determine whether common FKBP5 variants confer risk for bipolar disorder. We genotyped seven tag single-nucleotide polymorphisms (SNPs) in...
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