Article
Bradykinin type 2 receptor BE1 genotype influences bradykinin-dependent vasodilation during angiotensin-converting enzyme inhibition.
Hypertension (Dallas, Tex. : 1979) - 1 Feb 2008
Van Guilder Gary P, Pretorius Mias, Luther James M, Byrd J Brian, Hill Kevin, Gainer James V, Brown Nancy J
Abstract excerpt
To test the hypothesis that the bradykinin receptor 2 (BDKRB2) BE1+9/-9 polymorphism affects vascular responses to bradykinin, we measured the effect of intra-arterial bradykinin on forearm blood flow and tissue-type plasminogen activator (t-PA) release in 89 normotensive, nonsmoking, white American subjects in whom degradation of bradykinin was blocked by enalaprilat. BE1 genotype frequencies were...
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