Article
Genetic variation and gender determine bradykinin type 1 receptor responses in human tissue: implications for the ACE-inhibitor-induced effects in patients with coronary artery disease.
Clinical science (London, England : 1979) - 1 Mar 2014
Wu Haiyan, Roks Anton J M, Leijten Frank P J, Garrelds Ingrid M, Musterd-Bhaggoe Usha M, van den Bogaerdt Antoon J, de Maat Moniek P M, Simoons Maarten L, Danser A H Jan, Oeseburg Hisko
Abstract excerpt
The efficacy of the ACE (angiotensin-converting enzyme) inhibitor perindopril in coronary artery disease [EUROPA (European trial on reduction of cardiac events with perindopril in stable coronary artery disease) study] is associated with the rs12050217 A/G single nucleotide polymorphism in the B1 receptor (bradykinin type 1 receptor) gene. To investigate the underlying mechanism, we examined the effect of this...
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