Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alternate Cyclin D1 mRNA Splicing Modulates p27KIP1 Binding and Cell Migration

7 Jan 2008

Abstract excerpt

Cyclin D1 is an important cell cycle regulator, but in cancer its overexpression also increases cellular migration mediated by p27 KIP1 stabilization and RhoA inhibition. Recently, a common polymorphism at the exon 4-intron 4 boundary of the human cyclin D1 gene within a splice donor region was associated with an altered risk of developing cancer. Altered RNA splicing caused by this polymorphism gives rise to a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to RNA modifications and cancer
Share to RNA Research and Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18180298
DOI: 10.1074/jbc.m706992200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alternate Cyclin D1 mRNA Splicing Modulates p27KIP1 Binding and Cell MigrationPMID 18180298Read ↗

Alternative Cyclin D1 Splice Forms Differentially Regulate the DNA Damage ResponseSemantic proximity Read ↗

Cyclin D1 splice variants. Differential effects on localization, RB phosphorylation, and cellular transformation.Semantic proximity Read ↗

The cyclin D1b splice variant: an old oncogene learns new tricks.Semantic proximity Read ↗

Aberrant Cyclin D1 splicing in cancer: from molecular mechanism to therapeutic modulation.Semantic proximity Read ↗

Cyclin D1b splice variant promotes αvβ3-mediated adhesion and invasive migration of breast cancer cells.Semantic proximity Read ↗

Cyclin D1 Induction of Cellular Migration Requires p27KIP1Semantic proximity Read ↗

Alternative Splicing of the Human Cyclin D-binding Myb-like Protein (hDMP1) Yields a Truncated Protein Isoform That Alters Macrophage Differentiation PatternsSemantic proximity Read ↗

Cyclin D1 regulates cellular migration through the inhibition of thrombospondin 1 and ROCK signaling.Semantic proximity Read ↗

Cyclin D1 Functions in Cell MigrationSemantic proximity Read ↗

Functions of cyclin D1 as an oncogene and regulation of cyclin D1 expressionSemantic proximity Read ↗

Cyclin D1, Id1 and EMT in breast cancerSemantic proximity Read ↗

Induced expression of human CCND1 alternative transcripts in mouse Cyl-1 knockout fibroblasts highlights functional differences.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.