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Article

Cyclin D1 Functions in Cell Migration

1 Nov 2006

Abstract excerpt

Cell migration is essential for developmental morphogenesis, tissue repair, and tumor metastasis. A recent study reveals that cyclin D1 acts to promote cell migration by inhibiting Rho/ROCK signaling and expression of thrombospondin-1 (TSP-1), an extracellular matrix protein that regulates cell migration in many settings including cancer. Given the frequent overexpression of cyclin D1 in cancer cells, due to its...

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PMID: 17106256
DOI: 10.4161/cc.5.21.3428

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