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Cyclin D1 Induction of Cellular Migration Requires p27KIP1

15 Oct 2006

Abstract excerpt

The cyclin D1 gene is amplified and overexpressed in human breast cancer, functioning as a collaborative oncogene. As the regulatory subunit of a holoenzyme phosphorylating Rb, cyclin D1 promotes cell cycle progression and a noncatalytic function has been described to sequester the cyclin-dependent kinase inhibitor protein p27. Cyclin D1 overexpression correlates with tumor metastasis and cyclin D1-deficient...

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PMID: 17047061
DOI: 10.1158/0008-5472.can-06-1596

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