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Functions of cyclin D1 as an oncogene and regulation of cyclin D1 expression

14 Mar 2007

Abstract excerpt

Cyclin D1 binds to the Cdk4 and Cdk6 to form a pRB kinase. Upon phosphorylation, pRB loses its repressive activity for the E2F transcription factor, which then activates transcription of several genes required for the transition from the G1- to S-phase and for DNA replication. The cyclin D1 gene is rearranged and overexpressed in centrocytic lymphomas and parathyroid tumors and it is amplified and/or...

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Identifiers

PMID: 17359287
DOI: 10.1111/j.1349-7006.2007.00449.x

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