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Article

Mast cells condition dendritic cells to mediate allograft tolerance.

Immunity - 28 Oct 2011

de Vries Victor C, Pino-Lagos Karina, Nowak Elizabeth C, Bennett Kathy A, Oliva Carla, Noelle Randolph J

Abstract excerpt

Peripheral tolerance orchestrated by regulatory T cells, dendritic cells (DCs), and mast cells (MCs) has been studied in several models including skin allograft tolerance. We now define a role for MCs in controlling DC behavior ("conditioning") to facilitate tolerance. Under tolerant conditions, we show that MCs mediated a marked increase in tumor necrosis factor (TNFα)-dependent accumulation of graft-derived DCs...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22035846
DOI: 10.1016/j.immuni.2011.09.012
PMCID: PMC3753083

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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