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Article

Integrin-like allosteric properties of the catch bond-forming FimH adhesin of Escherichia coli.

The Journal of biological chemistry - 21 Mar 2008

Tchesnokova Veronika, Aprikian Pavel, Yakovenko Olga, Larock Christopher, Kidd Brian, Vogel Viola, Thomas Wendy, Sokurenko Evgeni

Abstract excerpt

FimH is the adhesive subunit of type 1 fimbriae of the Escherichia coli that is composed of a mannose-binding lectin domain and a fimbria-incorporating pilin domain. FimH is able to interact with mannosylated surface via a shear-enhanced catch bond mechanism. We show that the FimH lectin domain possesses a ligand-induced binding site (LIBS), a type of allosterically regulated epitopes characterized in integrins....

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Share to Adhesins, Escherichia coli
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Source

Identifiers

PMID: 18174167
DOI: 10.1074/jbc.M707804200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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