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Article

Tight conformational coupling between the domains of the enterotoxigenic Escherichia coli fimbrial adhesin CfaE regulates binding state transition.

The Journal of biological chemistry - 5 Apr 2013

Liu Yang, Esser Lothar, Interlandi Gianluca, Kisiela Dagmara I, Tchesnokova Veronika, Thomas Wendy E, Sokurenko Evgeni, Xia Di, Savarino Stephen J

Abstract excerpt

CfaE, the tip adhesin of enterotoxigenic Escherichia coli colonization factor antigen I fimbriae, initiates binding of this enteropathogen to the small intestine. It comprises stacked β-sandwich adhesin (AD) and pilin (PD) domains, with the putative receptor-binding pocket at one pole and an equatorial interdomain interface. CfaE binding to erythrocytes is enhanced by application of moderate shear stress. A G168D...

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Identifiers

PMID: 23393133
DOI: 10.1074/jbc.M112.413534
PMCID: PMC3617298

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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