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Article

Breakdown in repression of IFN-γ mRNA leads to accumulation of self-reactive effector CD8+ T cells.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 2012

Chang Pheh-Ping, Lee Sau K, Hu Xin, Davey Gayle, Duan Guowen, Cho Jae-Ho, Karupiah Guna, Sprent Jonathan, Heath William R, Bertram Edward M, Vinuesa Carola G

Abstract excerpt

Tight regulation of virus-induced cytotoxic effector CD8(+) T cells is essential to prevent immunopathology. Naturally occurring effector CD8(+) T cells, with a KLRG1(hi) CD62L(lo) phenotype typical of short-lived effector CD8(+) T cells (SLECs), can be found in increased numbers in autoimmune-pr...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22685317
DOI: 10.4049/jimmunol.1102432

Genes

KLRG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22685317-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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