Mutation analysis of the checkpoint kinase 2 gene in colorectal cancer cell lines.

Abstract excerpt

BACKGROUND: Checkpoint kinase 2 (CHK2) is a DNA damage-activated protein kinase which is involved in cell cycle checkpoint control. CHK2 gene could be a candidate gene for colorectal cancer susceptibility. But there are few systematic reports on mutation of CHK2 in colorectal cancer. METHODS: The mutations of all 14 exons of CHK2 in 56 colorectal cancer cell lines were screened systematically, using denaturing...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cell Line, Tumor
• Share to Checkpoint Kinase 2
• Share to Chromatography, High Pressure Liquid