Article
Association between a disrupted-in-schizophrenia 1 (DISC1) single nucleotide polymorphism and schizophrenia in a combined Scandinavian case-control sample.
Schizophrenia research - 1 Dec 2008
Saetre Peter, Agartz Ingrid, De Franciscis Alessandra, Lundmark Per, Djurovic Srdjan, Kähler Anna, Andreassen Ole A, Jakobsen Klaus D, Rasmussen Henrik B, Werge Thomas, Hall Håkan, Terenius Lars, Jönsson Erik G
Abstract excerpt
Disrupted-in-schizophrenia-1 (DISC1), located on chromosome 1q42.1, is linked to rare familial schizophrenia in a large Scottish family. The chromosomal translocation that segregates with the disease results in a truncated protein that impairs neurite outgrowth and proper development of the cerebral cortex, suggesting that lost DISC1 function may underlie neurodevelopmental dysfunction in schizophrenia. DISC1 has...
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