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H7N9 Influenza Virus Containing a Polybasic HA Cleavage Site Requires Minimal Host Adaptation to Obtain a Highly Pathogenic Disease Phenotype in Mice.

Viruses - 5 Jan 2020

Chan Mable, Leung Anders, Hisanaga Tamiko, Pickering Brad, Griffin Bryan D, Vendramelli Robert, Tailor Nikesh, Wong Gary, Bi Yuhai, Babiuk Shawn, Berhane Yohannes, Kobasa Darwyn

Abstract excerpt

Low pathogenic avian influenza (LPAI) H7N9 viruses have recently evolved to gain a polybasic cleavage site in the hemagglutinin (HA) protein, resulting in variants with increased lethality in poultry that meet the criteria for highly pathogenic avian influenza (HPAI) viruses. Both LPAI and HPAI variants can cause severe disease in humans (case fatality rate of ~40%). Here, we investigated the virulence of HPAI...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Influenza A Virus, H7N9 Subtype

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Identifiers

PMID: 31948040
DOI: 10.3390/v12010065
PMCID: PMC7020020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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