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Article

The neuronal nicotinic receptor subunit genes (CHRNA6 and CHRNB3) are associated with subjective responses to tobacco.

Human molecular genetics - 1 Mar 2008

Zeiger Joanna S, Haberstick Brett C, Schlaepfer Isabel, Collins Allan C, Corley Robin P, Crowley Thomas J, Hewitt John K, Hopfer Christian J, Lessem Jeffrey, McQueen Matthew B, Rhee Soo Hyun, Ehringer Marissa A

Abstract excerpt

Neuronal nicotinic acetylcholine receptors have been implicated in various measures of nicotine dependence. In this paper, we present findings from an exploratory study of single nucleotide polymorphisms (SNPs) in the CHRNB3 and CHRNA6 genes with tobacco and alcohol phenotypes, including frequency of use and three subjective response factors occurring shortly after initiation of use. Subjects were 1056 ethnically...

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Source

Identifiers

PMID: 18055561
DOI: 10.1093/hmg/ddm344

Genes

CHRNB3
CHRNA6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The neuronal nicotinic receptor subunit genes (CHRNA6 and CHRNB3) are associated with subjective responses to tobacco.PMID 18055561Read ↗

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Genetic association of the CHRNA6 and CHRNB3 genes with tobacco dependence in a nationally representative sample.Semantic proximity Read ↗

SNPs in CHRNA6 and CHRNB3 are associated with alcohol consumption in a nationally representative sample.Semantic proximity Read ↗

Alpha-5 and -3 nicotinic receptor gene variants predict nicotine dependence but not cessation: findings from the COMMIT cohort.Semantic proximity Read ↗

CHRNB2 promoter region: association with subjective effects to nicotine and gene expression differences.Semantic proximity Read ↗

Nicotinic receptor gene variants interact with attention deficient hyperactive disorder symptoms to predict smoking trajectories from early adolescence to adulthood.Semantic proximity Read ↗

Association of CHRN genes with "dizziness" to tobacco.Semantic proximity Read ↗

Effect of neuronal nicotinic acetylcholine receptor genes (CHRN) on longitudinal cigarettes per day in adolescents and young adults.Semantic proximity Read ↗

Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes.Semantic proximity Read ↗

The CHRNA5/A3/B4 gene cluster variability as an important determinant of early alcohol and tobacco initiation in young adults.Semantic proximity Read ↗

Distinct loci in the CHRNA5/CHRNA3/CHRNB4 gene cluster are associated with onset of regular smoking.Semantic proximity Read ↗

A candidate gene approach identifies the CHRNA5-A3-B4 region as a risk factor for age-dependent nicotine addiction.Semantic proximity Read ↗

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