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Article

Functional characterization of SNPs in CHRNA3/B4 intergenic region associated with drug behaviors.

Brain research - 5 Sept 2013

Flora Amber V, Zambrano Cristian A, Gallego Xavier, Miyamoto Jill H, Johnson Krista A, Cowan Katelyn A, Stitzel Jerry A, Ehringer Marissa A

Abstract excerpt

The cluster of human neuronal nicotinic receptor genes (CHRNA5/A3/B4) (15q25.1) has been associated with a variety of smoking and drug-related behaviors, as well as risk for lung cancer. CHRNA3/B4 intergenic single nucleotide polymorphisms (SNPs) rs1948 and rs8023462 have been associated with early initiation of alcohol and tobacco use, and rs6495309 has been associated with nicotine dependence and risk for lung...

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Source

Open in PubMed Open full text

Identifiers

PMID: 23872218
DOI: 10.1016/j.brainres.2013.07.017
PMCID: PMC3839343

Genes

CHRNA3
CHRNA5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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