Association between PPAR-γ2 Pro12Ala genotype and insulin resistance is modified by circulating lipids in Mexican children.

doi:10.1038/srep24472

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Article

Association between PPAR-γ2 Pro12Ala genotype and insulin resistance is modified by circulating lipids in Mexican children.

Scientific reports - 14 Apr 2016

Stryjecki Carolina, Peralta-Romero Jesus, Alyass Akram, Karam-Araujo Roberto, Suarez Fernando, Gomez-Zamudio Jaime, Burguete-Garcia Ana, Cruz Miguel, Meyre David

Abstract excerpt

The Pro12Ala (rs1801282) polymorphism in peroxisome proliferator-activated receptor-γ2 (PPAR-γ2) has been convincingly associated with insulin resistance (IR) and type 2 diabetes (T2D) among Europeans, in interaction with a high-fat diet. Mexico is disproportionally affected by obesity and T2D however, whether the Pro12Ala polymorphism is associated with early metabolic complications in this population is...

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PMID: 27075119
DOI: 10.1038/srep24472
PMCID: PMC4830984

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